Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.50 |
| ▸ | DRD2 | P14416 | 7/20 | 0.50 |
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263295 | 0.85 | ADRA1A (0.55) | ADRA1ADRD2DRD3ADRA1DADRA1B | |
| SCHEMBL27263977 | 0.81 | BRD4 (0.41) | ADRA1ADRD2ADRA1DADRA1BHTR1A | |
| SCHEMBL27264050 | 0.81 | ADRA1D (0.42) | ADRA1AADRA1DADRA1BHTR1AKAT2B | |
| SCHEMBL27263292 | 0.81 | ADRA1A (0.56) | ADRA1ADRD2DRD3ADRA1DADRA1B | |
| SCHEMBL27263072 | 0.80 | BPTF (0.46) | ADRA1ADRD2ADRA1DADRA1BHTR1A | |
| SCHEMBL27263765 | 0.80 | KAT2B (0.52) | ADRA1ADRD3ADRA1DADRA1BHTR1A | |
| SCHEMBL27263873 | 0.80 | ADRA1D (0.52) | ADRA1AADRA1DADRA1BHTR1A | |
| SCHEMBL9528850 | 0.79 | BPTF (0.49) | ADRA1ADRD2DRD3ADRA1DADRA1B | |
| SCHEMBL27263753 | 0.79 | MAPT (0.44) | ADRA1ADRD3ADRA1DADRA1BDRD1 | |
| SCHEMBL27263862 | 0.79 | DRD2 (0.49) | ADRA1ADRD2DRD3ADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |