Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532001 | 0.85 | KAT2B (0.59) | BPTFDRD4HTR1ADRD2HTR2A | |
| SCHEMBL9527024 | 0.85 | BPTF (0.53) | BPTFHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9531556 | 0.82 | ADRA1A (0.53) | BPTFHTR1ADRD2HTR7DRD3 | |
| SCHEMBL9528841 | 0.81 | ADRA1B (0.55) | BPTFHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9528184 | 0.81 | ADRA1A (0.58) | BPTFHTR1ADRD2HTR2ADRD3 | |
| SCHEMBL9527111 | 0.81 | BPTF (0.51) | BPTFHTR1AHTR7KAT2BADRA1D | |
| SCHEMBL9526815 | 0.81 | HTR1A (0.47) | DRD4HTR1AHTR7ADRA1DADRA1A | |
| SCHEMBL9527290 | 0.80 | KCNH2 (0.51) | BPTFDRD4DRD2KMT2A | |
| SCHEMBL9526962 | 0.80 | KAT2B (0.57) | HTR1ADRD2HTR2AHTR2CHTR7 | |
| SCHEMBL9526736 | 0.80 | ADRA1A (0.62) | DRD4HTR1ADRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |