Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724549 | 0.95 | ACMSD (0.48) | ACMSDHDAC1HDAC2HDAC3SERPINE1 | |
| SCHEMBL6069021 | 0.76 | ACMSD (0.61) | ACMSDHDAC1HDAC2HDAC3SERPINE1 | |
| SCHEMBL31554955 | 0.76 | SERPINE1 (0.59) | ACMSDHDAC1HDAC2HDAC3SERPINE1 | |
| SCHEMBL417671 | 0.76 | SERPINE1 (0.59) | ACMSDHDAC1HDAC2HDAC3SERPINE1 | |
| SCHEMBL2724261 | 0.76 | IKBKE (0.42) | TBK1IKBKEMEN1ALDH1A1KMT2A | |
| SCHEMBL1142393 | 0.75 | KDM4E (0.50) | MEN1ALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL27296967 | 0.75 | ACMSD (0.49) | ACMSDHDAC1HDAC2HDAC3SERPINE1 | |
| SCHEMBL109155 | 0.73 | KDM4E (0.56) | MEN1ALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL6051820 | 0.71 | ACMSD (0.56) | ACMSDSERPINE1MEN1ALDH1A1KMT2A | |
| SCHEMBL1477467 | 0.71 | KDM4E (0.54) | MEN1ALDH1A1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635279-A2 | CHEMICAL COMPOUNDS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-11 | — | — | EP | disclosed |
| US-20130225524-A1 | Chemical Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2013-08-29 | — | — | US | disclosed |
| WO-2012061557-A2 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225524-A1 | Chemical Compounds | LDHA, NQO2, LDHB | ACMSD 2708/4885HDAC1 654/4885HDAC2 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.