Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | FABP7 | O15540 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DDO | Q99489 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29858668 | 0.83 | ATAD2 (0.47) | IKBKETBK1FABP7CYP11B2PRKDC | |
| SCHEMBL30381089 | 0.80 | NPC1 (0.45) | FABP7PIK3CAPIK3CDLMNAMAPK1 | |
| SCHEMBL420951 | 0.78 | IKBKE (0.44) | IKBKETBK1FABP7FABP5FABP3 | |
| SCHEMBL3107969 | 0.78 | FABP7 (0.53) | IKBKETBK1FABP7FABP5FABP3 | |
| SCHEMBL31705648 | 0.78 | FABP7 (0.53) | IKBKETBK1FABP7FABP5FABP3 | |
| SCHEMBL2724549 | 0.77 | ACMSD (0.48) | IKBKETBK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL31704858 | 0.77 | CYP11B2 (0.51) | IKBKETBK1FABP7CYP11B2PIK3CA | |
| SCHEMBL31706135 | 0.77 | CYP11B2 (0.51) | IKBKETBK1FABP7CYP11B2PIK3CA | |
| SCHEMBL2726495 | 0.76 | ACMSD (0.49) | IKBKETBK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL22032867 | 0.75 | PIK3CA (0.39) | IKBKETBK1FABP7CYP11B2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635279-A2 | CHEMICAL COMPOUNDS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-11 | — | — | EP | disclosed |
| US-20130225524-A1 | Chemical Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2013-08-29 | — | — | US | disclosed |
| WO-2012061557-A2 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225524-A1 | Chemical Compounds | LDHA, NQO2, LDHB | IKBKE 2944/4885TBK1 4103/4885FABP7 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.