Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164805 | 0.76 | CYP1A2 (0.46) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL10492340 | 0.71 | CYP11B1 (0.46) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL1299174 | 0.70 | TBXAS1 (0.51) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL29520054 | 0.70 | CHRNA7 (0.44) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL10492186 | 0.68 | HTT (0.47) | CHRNB2CHRNA4CYP1A2CYP2D6HRH4 | |
| SCHEMBL27606289 | 0.68 | MPO (0.43) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL727185 | 0.67 | CYP1A2 (0.62) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL27606285 | 0.67 | CHRNA7 (0.45) | CHRNB2CHRNA4CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL3992249 | 0.67 | PDE10A (0.64) | PDE10AMEN1MAPTKMT2A | |
| SCHEMBL694101 | 0.67 | HRH4 (0.47) | HRH4HRH3MMP2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1021823-C | Substituted chroman compounds for treatment of asthma, arthritis and the like | PFIZER (US) | 1993-08-18 | — | — | CN | disclosed |
| CN-1064864-A | The tetraline that replaces and the preparation method of allied compound | PFIZER (US) | 1992-09-30 | — | — | CN | disclosed |
| CN-1063489-A | Substituted benzotetrahydropyridines and related compounds | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |