SCHEMBL27268908

SCHEMBL27268908

CC(C)(C)OC(=O)N1CCN(C2CCC(NC(=O)Cc3c(F)cccc3Br)CC2F)CC1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 7/20 0.49
▸ KMT2A Q03164 1/20 0.40
▸ ALDH1A1 P00352 3/20 0.39
▸ SIGMAR1 Q99720 1/20 0.38
▸ KDM1A O60341 1/20 0.37
▸ NPC1 O15118 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ DPP4 P27487 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ PKM P14618 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27268939 0.87 GPR119 (0.53) GPR119KMT2AALDH1A1SIGMAR1KDM1A
SCHEMBL27268965 0.79 ALDH1A1 (0.46) GPR119KMT2AALDH1A1SIGMAR1HTT
SCHEMBL27268982 0.70 PRKCG (0.40) GPR119DPP4
SCHEMBL30962055 0.70 PRKCG (0.40) GPR119DPP4
SCHEMBL30962059 0.69 SCN9A (0.39) GPR119MAPTDPP4
SCHEMBL30962013 0.69 SCN9A (0.39) GPR119MAPTDPP4
SCHEMBL30962071 0.69 SCN9A (0.39) GPR119MAPTDPP4
SCHEMBL30962048 0.69 SCN9A (0.39) GPR119MAPTDPP4
SCHEMBL27268851 0.69 CHRM2 (0.42) GPR119ALDH1A1NPC1MAPTMAPK1
SCHEMBL13060212 0.68 GPR119 (0.59) GPR119ALDH1A1KDM1ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4638442-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS Uniquest Pty Limited (AU) 2025-10-29 — — EP disclosed
WO-2024130342-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS UNIQUEST PTY LIMITED (AU) 2024-06-27 — — WO disclosed
WO-2024130342-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS UNIQUEST PTY LIMITED (AU) 2024-06-27 — — WO disclosed
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