Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.53 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | RXRG | P48443 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL15389444 | 1.00 | KARS1 (0.54) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL2728234 | 1.00 | KARS1 (0.54) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL2727940 | 0.98 | KARS1 (0.53) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL15389438 | 0.98 | KARS1 (0.53) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL2727937 | 0.98 | KARS1 (0.53) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL2729901 | 0.95 | KARS1 (0.55) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL2729902 | 0.95 | KARS1 (0.55) | KARS1RXRACCNE1CDK2RXRB | |
| Fumaric Acid SCHEMBL15899533 | 0.95 | KARS1 (0.55) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL2728721 | 0.87 | KARS1 (0.59) | KARS1RXRACCNE1CDK2RXRB | |
| SCHEMBL2728719 | 0.87 | KARS1 (0.59) | KARS1RXRACCNE1CDK2RXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822692-B2 | Diterpenoid derivatives endowed of biological properties | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE, S.P.A. (IT) | 2014-09-02 | — | — | US | disclosed |
| EP-2632892-B1 | DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES | SIGMA TAU IND FARMACEUTI (IT) | 2014-07-30 | — | — | EP | disclosed |
| US-20130310423-A1 | DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2013-11-21 | — | — | US | disclosed |
| EP-2632892-A1 | DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012055894-A1 | DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310423-A1 | DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES | PTGIS, CYP11B2, CYP11B1 | MEN1 2276/4885KMT2A 4440/4885KARS1 4322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.