Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 10/20 | 0.51 |
| ▸ | JAK2 | O60674 | 7/20 | 0.51 |
| ▸ | JAK1 | P23458 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GALK1 | P51570 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155966 | 0.76 | ALDH1A1 (0.61) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL10289215 | 0.73 | ALDH1A1 (0.57) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL4377125 | 0.72 | ALDH1A1 (0.56) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL4157657 | 0.72 | DOT1L (0.56) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL19541876 | 0.71 | HPGD (0.56) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL8903199 | 0.71 | NLRP3 (0.40) | TYK2ALDH1A1GAAMAPT | |
| SCHEMBL15038350 | 0.71 | ALDH1A1 (0.65) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL20387787 | 0.70 | PKM (0.54) | ALDH1A1GAAHPGDRAB9A | |
| SCHEMBL11005407 | 0.70 | ALDH1A1 (0.56) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL8857056 | 0.69 | GAA (0.53) | POLBTYK2JAK2JAK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1039590-A | Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates | DOW CHEMICAL CO (US) | 1990-02-14 | — | — | CN | claimed |
| CN-1037605-C | Alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamides, process for their preparation and intermediates | DOW CHEMICAL CO (US) | 1998-03-04 | — | — | CN | disclosed |
| CN-1030606-C | Alkoxy-1, 2, 3-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, their preparation and their use | DOW CHEMICAL CO (US) | 1996-01-03 | — | — | CN | disclosed |
| CN-1106010-A | Alkoxy-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamides, process for their preparation and intermediates | DOW CHEMICAL CO (US) | 1995-08-02 | — | — | CN | disclosed |
| CN-1039590-A | Alkoxy-1, 2, 4-triazolo [1, 5-C ] pyrimidine-2-sulfonamides, processes for their preparation and intermediates | DOW CHEMICAL CO (US) | 1990-02-14 | — | — | CN | disclosed |