Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9771551 | 0.84 | MAPT (0.41) | NLRP3TYK2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL8903164 | 0.76 | ALDH1A1 (0.51) | TSHRMAPTGAAALDH1A1AKR1B10 | |
| SCHEMBL8945494 | 0.75 | ADRA2A (0.39) | TSHRTYK2GAAADRA1AADRA2A | |
| SCHEMBL8903124 | 0.74 | NLRP3 (0.40) | NLRP3GAAALDH1A1 | |
| SCHEMBL27287656 | 0.71 | POLB (0.53) | TYK2MAPTGAAALDH1A1 | |
| SCHEMBL7350648 | 0.70 | CYP1A2 (0.43) | NLRP3TSHRMAPTL3MBTL1GAA | |
| SCHEMBL7704551 | 0.67 | MAPT (0.56) | NLRP3TSHRTYK2MAPTL3MBTL1 | |
| SCHEMBL11802445 | 0.67 | TSHR (0.50) | TSHRTYK2GAAPDK1PDK2 | |
| SCHEMBL7534755 | 0.67 | MAPK14 (0.43) | NLRP3TSHRGAA | |
| SCHEMBL463746 | 0.66 | CYP1A2 (0.43) | TSHRTYK2GAAADRA1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2598540-B2 | — | — | 1997-04-09 | — | — | JP | claimed |
| WO-1989011782-A1 | ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES | THE DOW CHEMICAL COMPANY (US) | 1989-12-14 | — | — | WO | claimed |
| EP-0343752-A1 | Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates | DowElanco (US) | 1989-11-29 | — | — | EP | claimed |