Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795991 | 0.75 | CHEK2 (0.46) | EGFRPDGFRBPDGFRAKDRSMN1; SMN2 | |
| SCHEMBL3714860 | 0.74 | KCNA5 (0.49) | SMN1; SMN2NPC1RAB9APARP1HSD17B10 | |
| SCHEMBL7448803 | 0.72 | ALDH1A1 (0.55) | SMN1; SMN2TSHRNPC1RAB9AAURKA | |
| SCHEMBL2770958 | 0.72 | PARP1 (0.51) | SMN1; SMN2LMNATSHRNPC1RAB9A | |
| SCHEMBL3523972 | 0.71 | NPC1 (0.47) | SMN1; SMN2NPC1RAB9APOLBKMT2A | |
| SCHEMBL6796063 | 0.70 | PARP1 (0.49) | SMN1; SMN2LMNATSHRNPC1RAB9A | |
| SCHEMBL2728976 | 0.69 | AURKA (0.67) | KDRTSHRAURKARPS6KB1MAP4K2 | |
| SCHEMBL3716902 | 0.68 | PARP1 (0.44) | SMN1; SMN2LMNANPC1RAB9APARP1 | |
| SCHEMBL16340275 | 0.68 | HPGD (0.54) | EGFRPDGFRBPDGFRAKDRSMN1; SMN2 | |
| SCHEMBL4894330 | 0.68 | EGFR (0.59) | EGFRPDGFRBPDGFRAKDRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |