Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448803 | 0.78 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDNPC1MAPT | |
| SCHEMBL2770958 | 0.78 | PARP1 (0.51) | PARP1TDP1KDM4EALDH1A1HPGD | |
| SCHEMBL10094607 | 0.77 | KCNA5 (0.57) | KCNA5NOTUMGRM5 | |
| SCHEMBL913751 | 0.76 | MKNK1 (0.44) | MKNK1MKNK2SIRT3F7F3 | |
| SCHEMBL2062944 | 0.75 | KCNA5 (0.67) | KCNA5MKNK1MKNK2NOTUMGRM5 | |
| SCHEMBL10427732 | 0.74 | NAPRT (0.51) | TDP1KDM4EALDH1A1NPC1MAPT | |
| SCHEMBL2728969 | 0.74 | EGFR (0.47) | PARP1ALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL2062668 | 0.74 | KCNA5 (0.51) | KCNA5NOTUMGRM5MAPT | |
| SCHEMBL27549059 | 0.72 | KCNA5 (0.51) | KCNA5NOTUMALDH1A1GRM5 | |
| SCHEMBL6796063 | 0.72 | PARP1 (0.49) | MKNK1MKNK2PARP1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |