Acrylamide — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	FGFR4 known ✓	P22455	1/20	0.58

▸	ALDH1A1	P00352	4/20	0.58

▸	TSHR	P16473	3/20	0.58

▸	TDP1	Q9NUW8	1/20	0.41

▸	TP53	P04637	1/20	0.38

▸	LMNA	P02545	2/20	0.35

▸	ALOX15	P16050	1/20	0.35

▸	BLM	P54132	1/20	0.35

▸	PMP22	Q01453	1/20	0.35

▸	CA4	P22748	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acrylamide SCHEMBL16402988	0.89	ALDH1A1 (0.73)	ALDH1A1TSHRFGFR4TDP1LMNA
Acrylamide SCHEMBL2160931	0.89	ALDH1A1 (0.73)	ALDH1A1TSHRFGFR4TDP1LMNA
Acrylamide SCHEMBL4052693	0.89	ALDH1A1 (0.73)	ALDH1A1TSHRFGFR4TDP1TP53
Acrylamide SCHEMBL29092492	0.89	ALDH1A1 (0.73)	ALDH1A1TSHRFGFR4TDP1LMNA
Acrylamide SCHEMBL28918491	0.89	ALDH1A1 (0.73)	ALDH1A1TSHRFGFR4TDP1LMNA
Acrylamide SCHEMBL23493546	0.89	—	—
Acrylamide SCHEMBL28159490	0.86	ALDH1A1 (0.69)	ALDH1A1TSHRFGFR4TDP1TP53
Acrylamide SCHEMBL27770486	0.86	ALDH1A1 (0.69)	ALDH1A1TSHRFGFR4LMNACA4
Acrylamide SCHEMBL28734833	0.86	ALDH1A1 (0.69)	ALDH1A1TSHRFGFR4LMNACA4
Acrylamide SCHEMBL28807078	0.86	ALDH1A1 (0.69)	ALDH1A1TSHRFGFR4LMNACA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-1010897-B	HYDROPHILIC BASE MATERIAL OF OFFSET PLATE, MANUFACTURE PROCESS AND USE	HOECHST AG (DE)	1990-12-19	—	—	CN	claimed
CN-86101022-A	Hydrophilic supporting body material, its preparation method and the application of offset printing forme	—	1986-08-06	—	—	CN	claimed
CN-101195312-B	Hydrophilic dispersion liquid and printing plate base adopting the dispersion liquid	GUANGZHOU HUIGU CHEMISTRY CO LTD	2011-08-03	—	—	CN	disclosed
CN-101195312-A	Hydrophilic dispersion liquid and printing plate base adopting the dispersion liquid	GUANGZHOU HUIGU CHEMISTRY CO L (CN)	2008-06-11	—	—	CN	disclosed
CN-200967313-Y	Printing substrate having hydrophilic layer	GUANGZHOU HUIGU CHEMICALS CO L (CN)	2007-10-31	—	—	CN	disclosed
CN-1010897-B	HYDROPHILIC BASE MATERIAL OF OFFSET PLATE, MANUFACTURE PROCESS AND USE	HOECHST AG (DE)	1990-12-19	—	—	CN	disclosed
CN-86101022-A	Hydrophilic supporting body material, its preparation method and the application of offset printing forme	—	1986-08-06	—	—	CN	disclosed
CN-86101022-A	Hydrophilic supporting body material, its preparation method and the application of offset printing forme	—	1986-08-06	—	—	CN	disclosed