Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 8/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27293368 | 0.93 | TYK2 (0.45) | TYK2JAK1LRRK2 | |
| SCHEMBL27298318 | 0.91 | TYK2 (0.44) | TYK2JAK1 | |
| SCHEMBL27293273 | 0.82 | TYK2 (0.41) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31711666 | 0.80 | TYK2 (0.49) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27293253 | 0.80 | TYK2 (0.49) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27294058 | 0.80 | TYK2 (0.55) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27293389 | 0.80 | NPSR1 (0.42) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27417192 | 0.78 | JAK3 (0.49) | TYK2JAK1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL27293280 | 0.75 | SYK (0.41) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27293351 | 0.75 | NPSR1 (0.42) | TYK2JAK1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |