Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 14/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | CCR10 | P46092 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456849 | 0.83 | HTR7 (0.50) | HTR7DRD2HTR1DDRD3HTR2A | |
| SCHEMBL2729765 | 0.72 | HTR7 (0.74) | HTR7DRD2HTR1DDRD3HTR2A | |
| SCHEMBL8643575 | 0.72 | HTR7 (0.70) | HTR7DRD2HTR1DDRD3HTR2A | |
| SCHEMBL9225490 | 0.70 | KDM4E (0.46) | HSD11B1 | |
| SCHEMBL8557028 | 0.65 | CARM1 (0.55) | HTR7DRD2HTR1DDRD3SIGMAR1 | |
| SCHEMBL8557026 | 0.65 | CARM1 (0.55) | HTR7DRD2HTR1DDRD3SIGMAR1 | |
| SCHEMBL14375364 | 0.65 | SIGMAR1 (0.68) | SIGMAR1ACHE | |
| SCHEMBL24998551 | 0.65 | CCR8 (0.65) | — | |
| SCHEMBL9229962 | 0.63 | ALDH1A1 (0.45) | — | |
| Sb-258719 SCHEMBL29774472 | 0.63 | HTR7 (1.00) | HTR7DRD2HTR1DDRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049090-A1 | USE OF 5-HT7 RECEPTOR AGONISTS FOR THE TREATMENT OF PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008000495-A1 | USE OF 5-HT7 RECEPTOR AGONISTS FOR THE TREATMENT OF PAIN | LABORATORIOS DEL DR. ESTEVE, S.A (ES) | 2008-01-03 | — | — | WO | disclosed |