Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 16/20 | 1.00 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8593597 | 0.99 | HTR7 (0.98) | HTR7SLC6A9HTR2AHTR2CDRD2 | |
| SCHEMBL8643575 | 0.81 | HTR7 (0.70) | HTR7SLC6A9HTR2AHTR2CDRD2 | |
| SCHEMBL8647595 | 0.79 | HTR7 (0.72) | HTR7HTR2AHTR2CDRD2HTR1D | |
| SCHEMBL8554984 | 0.76 | HTR7 (0.62) | HTR7SLC6A9HTR2AHTR2CDRD2 | |
| SCHEMBL8552181 | 0.76 | HTR7 (0.77) | HTR7HTR2AHTR2CDRD2HTR1D | |
| SCHEMBL8648348 | 0.76 | SLC6A9 (0.67) | HTR7SLC6A9HRH3 | |
| SCHEMBL2729765 | 0.73 | HTR7 (0.74) | HTR7HTR2AHTR2CDRD2HTR1D | |
| SCHEMBL14382102 | 0.71 | SLC6A9 (1.00) | HTR7SLC6A9 | |
| SCHEMBL14382140 | 0.71 | SLC6A9 (1.00) | HTR7SLC6A9 | |
| SCHEMBL14520857 | 0.71 | HTR7 (0.67) | HTR7HTR2AHTR2CDRD2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | claimed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | claimed |
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |