Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 4/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 3/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225643 | 0.98 | TYR (0.70) | TYRUSP2GAAALOX15RAD51 | |
| Hydrochloric Acid SCHEMBL27297304 | 0.96 | TYR (0.68) | TYRUSP2GAAALOX15RAD51 | |
| SCHEMBL3334895 | 0.87 | TYR (0.71) | TYRUSP2GAAALOX15RAD51 | |
| SCHEMBL27500072 | 0.82 | USP2 (0.70) | TYRUSP2GAAALOX15RAD51 | |
| SCHEMBL34240 | 0.81 | TYR (1.00) | TYRUSP2GAAALOX15RAD51 | |
| SCHEMBL29355861 | 0.81 | TYR (1.00) | TYRUSP2GAAALOX15RAD51 | |
| SCHEMBL30253604 | 0.80 | NPC1 (0.71) | TYRFGFR1ENPP2NPC1AHR | |
| SCHEMBL443799 | 0.80 | NPC1 (0.71) | TYRFGFR1ENPP2NPC1AHR | |
| SCHEMBL147946 | 0.78 | AHR (0.70) | TYRESR1ENPP2NPC1AHR | |
| SCHEMBL13115618 | 0.78 | BRD4 (0.53) | TYRESR1ENPP2NPC1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037510-C | Indole derivatives | HOFFMANN LA ROCHE (CH) | 1998-02-25 | — | — | CN | disclosed |
| CN-1088576-A | Indole derivatives | HOFFMANN LA ROCHE (CH) | 1994-06-29 | — | — | CN | disclosed |