SCHEMBL2729935

SCHEMBL2729935

c1ccc(C(=Nc2ccccn2)c2ccccc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 4/20 0.59
ADRA2B P18089 4/20 0.59
ADRA2C P18825 4/20 0.59
PLAU P00749 1/20 0.59
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
AGTR1 P30556 1/20 0.47
NOS3 P29474 2/20 0.46
NOS1 P29475 2/20 0.46
NOS2 P35228 2/20 0.46
KMT2A Q03164 3/20 0.42
TDP1 Q9NUW8 2/20 0.41
KDM4E B2RXH2 3/20 0.41
LMNA P02545 2/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.41
CCR1 P32246 1/20 0.41
CCR5 P51681 1/20 0.41
CCR8 P51685 1/20 0.41
METAP1 P53582 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30189924 0.79 TBXA2R (0.42) ADRA2AADRA2BADRA2CPLAUKMT2A
SCHEMBL28294254 0.79 TBXA2R (0.42) ADRA2AADRA2BADRA2CPLAUKMT2A
Hydrochloric Acid SCHEMBL11378117 0.79 ADRA2A (0.56) ADRA2AADRA2BADRA2CPLAUMAOA
Hydrochloric Acid SCHEMBL11378120 0.79 ADRA2A (0.56) ADRA2AADRA2BADRA2CPLAUMAOA
SCHEMBL9957060 0.76 TBXA2R (0.40) ADRA2AADRA2BADRA2CPLAUAGTR1
SCHEMBL14911726 0.76 PLAU (0.42) ADRA2AADRA2BADRA2CPLAUAGTR1
SCHEMBL15018062 0.76 AGTR1 (0.36) ADRA2AADRA2BADRA2CPLAUMAOA
SCHEMBL30781991 0.76 ASIC3 (0.49) ADRA2AADRA2BADRA2CPLAUAGTR1
SCHEMBL30949907 0.74 KDM4C (0.54) PLAUKDM4E
SCHEMBL2226462 0.74 ADRA2A (1.00) ADRA2AADRA2BADRA2CPLAUNOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023165574-A1 COMPOUND USED AS TYK2 INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF 上海致根医药科技有限公司 2023-09-07 WO disclosed
EP-2632464-B1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL MERCK SHARP & DOHME (US) 2015-04-29 EP disclosed
US-20130253185-A1 NOVEL CATALYSTS DALHOUSIE UNIVERSITY (CA) 2013-09-26 US disclosed
US-20130253185-A1 NOVEL CATALYSTS DALHOUSIE UNIVERSITY (CA) 2013-09-26 US disclosed
EP-2632464-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Merck Sharp & Dohme Corp. (US) 2013-09-04 EP disclosed
WO-2012058134-A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL MERCK SHARP & DOHME CORP. (US) 2012-05-03 WO disclosed