Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945690 | 0.94 | SIRT6 (0.65) | KDM4EGAASIRT6LMNAHTR1A | |
| SCHEMBL1045292 | 0.88 | SIRT6 (0.69) | GAASIRT6LMNAHTR1APOLB | |
| SCHEMBL9436570 | 0.86 | HTR1A (0.58) | SIRT6LMNAHTR1APOLBMAPT | |
| SCHEMBL9747231 | 0.86 | SIRT6 (0.57) | SIRT6LMNAHTR1APOLBMAPT | |
| SCHEMBL19926115 | 0.86 | HTR1A (0.58) | SIRT6LMNAHTR1APOLBMAPT | |
| SCHEMBL3187195 | 0.84 | SIRT6 (0.59) | SIRT6LMNAHTR1APOLBMAPT | |
| SCHEMBL10511652 | 0.83 | LMNA (0.68) | GAASIRT6LMNAHTR1APOLB | |
| SCHEMBL5743368 | 0.83 | HTR1A (0.61) | SIRT6LMNAHTR1APOLBMAPT | |
| SCHEMBL5187796 | 0.83 | SIRT6 (0.60) | SIRT6LMNAHTR1APOLBMAPT | |
| SCHEMBL4507337 | 0.82 | SIRT6 (0.60) | SIRT6LMNAHTR1APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |