Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15486288 | 0.81 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11626453 | 0.77 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2729876 | 0.76 | KDM4E (0.42) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2997143 | 0.76 | CSNK2A1 (0.44) | MAPTMEN1KMT2AHPGDRXFP1 | |
| SCHEMBL5838270 | 0.74 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29391519 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2597652 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11625815 | 0.73 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL25229990 | 0.72 | NSD2 (0.61) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL30052735 | 0.72 | NSD2 (0.61) | KDM4EALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635567-B1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2015-10-28 | — | — | EP | disclosed |
| CN-103201276-B | Indole derivatives | RICHTER GEDEON NYRT | 2015-02-25 | — | — | CN | disclosed |
| EP-2635567-A1 | INDOLE DERIVATIVES | Richter Gedeon Nyrt. (HU) | 2013-09-11 | — | — | EP | disclosed |
| US-20130217702-A1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT. | 2013-08-22 | — | — | US | disclosed |
| CN-103201276-A | Indole derivatives | RICHTER GEDEON NYRT | 2013-07-10 | — | — | CN | disclosed |
| WO-2012059776-A1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217702-A1 | INDOLE DERIVATIVES | BDKRB1, BDKRB2, ARRB1 | KDM4E 3663/4885ALDH1A1 1752/4885MAPT 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.