Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24684941 | 0.84 | HSD11B1 (0.56) | HSD11B1USP30MEN1KMT2AGPR119 | |
| SCHEMBL26666679 | 0.82 | HSD11B1 (0.54) | HSD11B1USP30GPR119KDM4DSPR | |
| SCHEMBL29133796 | 0.82 | HSD11B1 (0.54) | HSD11B1USP30MEN1KMT2AGPR119 | |
| SCHEMBL803844 | 0.79 | HSD11B1 (0.45) | HSD11B1ALDH1A1POLBCTSDCTSL | |
| SCHEMBL14273589 | 0.79 | HSD11B1 (0.58) | HSD11B1ALDH1A1USP30MEN1KMT2A | |
| SCHEMBL8912028 | 0.79 | HSD11B1 (0.50) | HSD11B1ALDH1A1POLBUSP30LMNA | |
| SCHEMBL8716875 | 0.78 | HSD11B1 (0.51) | HSD11B1USP30GPR119KDM4DSPR | |
| SCHEMBL2053864 | 0.78 | HSD11B1 (0.47) | HSD11B1SMN1; SMN2USP30GPR119KDM4D | |
| SCHEMBL190837 | 0.78 | HSD11B1 (0.47) | HSD11B1USP30GPR119KDM4D | |
| SCHEMBL17828655 | 0.77 | HPGD (0.47) | SMN1; SMN2USP30MEN1KMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024003533-A1 | PROTACS FOR TARGETED DEGRADATION OF KAT2A AND KAT2B FOR THE TREATMENT OF CANCER | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2024-01-04 | — | — | WO | disclosed |