SCHEMBL27313907

SCHEMBL27313907

CCCC(C(=O)OCC)c1ccc(C#Cc2cc3c(cc2CC)OCCC3(C)C)cc1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.38
HNF4A P41235 1/20 0.38
RARA P10276 5/20 0.33
RARB P10826 5/20 0.33
RARG P13631 5/20 0.33
CYP3A4 P08684 2/20 0.33
KMT2A Q03164 1/20 0.33
ACACB O00763 3/20 0.33
CYP26A1 O43174 2/20 0.31
CRABP2 P29373 1/20 0.31
CYP26B1 Q9NR63 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27314939 0.93 RXRA (0.36) RXRAHNF4ARARARARBRARG
SCHEMBL9817739 0.92 RXRA (0.38) RXRAHNF4ARARARARBRARG
SCHEMBL27304402 0.92 RXRA (0.35) RXRAHNF4ARARARARBRARG
SCHEMBL9817832 0.89 RXRA (0.36) RXRAHNF4ARARARARBRARG
SCHEMBL9817708 0.87 RXRA (0.35) RXRAHNF4ARARARARBRARG
SCHEMBL9817789 0.86 RXRA (0.35) RXRAHNF4ARARARARBRARG
SCHEMBL9817801 0.85 RXRA (0.34) RXRAHNF4ARARARARBRARG
SCHEMBL9817783 0.84 RXRA (0.34) RXRAHNF4ARARARARBRARG
SCHEMBL9817647 0.83 RARA (0.46) RXRAHNF4ARARARARBRARG
SCHEMBL9817823 0.83 RARB (0.47) RXRARARARARBRARGCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1032204-C Acetylenes disubstituted with phenyl group and heterobicyclic group having retinoid like activity ALLERGEN INC (US) 1996-07-03 CN disclosed