Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 3/20 | 0.32 |
| ▸ | RARB | P10826 | 3/20 | 0.32 |
| ▸ | RARG | P13631 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9817708 | 0.95 | RXRA (0.35) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL9817789 | 0.94 | RXRA (0.35) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL9817801 | 0.93 | RXRA (0.34) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL9817783 | 0.92 | RXRA (0.34) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL9817739 | 0.90 | RXRA (0.38) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL27313907 | 0.89 | RXRA (0.38) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL27314939 | 0.86 | RXRA (0.36) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL27304402 | 0.84 | RXRA (0.35) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL9817844 | 0.84 | RARA (0.44) | RXRAHNF4ARARARARBRARG | |
| SCHEMBL9817834 | 0.84 | ACACB (0.31) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290130-B1 | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4810804-A | PSORIASIS | ALLERGAN, INC. (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0290130-A1 | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity | ALLERGAN, INC (US) | 1988-11-09 | — | — | EP | disclosed |