Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27320131 | 0.86 | ALDH1A1 (0.41) | MAP4K4SHMT2DRD4HTR1ADRD2 | |
| SCHEMBL27320077 | 0.82 | HRH3 (0.47) | ACHEPDE9ADRD4DRD2PDE2A | |
| SCHEMBL27320705 | 0.80 | ALDH1A1 (0.39) | MAP4K4SHMT2OPRK1PDE2AOPRM1 | |
| SCHEMBL27320436 | 0.76 | HRH3 (0.46) | ACHEHRH3KCNH2 | |
| SCHEMBL27320503 | 0.73 | HRH3 (0.37) | MAP4K4DRD4DRD2HRH3KCNH2 | |
| SCHEMBL27320154 | 0.72 | HRH3 (0.46) | ACHEMAP4K4DRD4HTR1ADRD2 | |
| SCHEMBL27320556 | 0.71 | HRH3 (0.36) | MAP4K4PDE2AHRH3KCNH2 | |
| SCHEMBL27152973 | 0.71 | KDM4E (0.38) | SHMT2OPRK1OPRM1 | |
| SCHEMBL30718666 | 0.71 | KDM4E (0.38) | SHMT2OPRK1OPRM1 | |
| SCHEMBL31413470 | 0.68 | SHMT2 (0.35) | SHMT2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |