Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27320131 | 0.93 | ALDH1A1 (0.41) | ALDH1A1HTTSHMT2MCHR1MAP4K4 | |
| SCHEMBL27320336 | 0.81 | HRH3 (0.47) | ALDH1A1HTTHRH3SMN1; SMN2 | |
| SCHEMBL27320321 | 0.80 | ACHE (0.39) | SHMT2MAP4K4HRH3OPRK1OPRM1 | |
| SCHEMBL27320503 | 0.80 | HRH3 (0.37) | MCHR1MAP4K4HRH3SMN1; SMN2 | |
| SCHEMBL27320556 | 0.78 | HRH3 (0.36) | ALDH1A1MCHR1MAP4K4HRH3PDE2A | |
| SCHEMBL27320384 | 0.76 | ALDH1A1 (0.37) | ALDH1A1HTTMCHR1MAP4K4HTR2C | |
| SCHEMBL27140449 | 0.76 | SHMT2 (0.34) | SHMT2SMN1; SMN2OPRK1OPRM1 | |
| SCHEMBL30718558 | 0.76 | SHMT2 (0.34) | SHMT2SMN1; SMN2OPRK1OPRM1 | |
| SCHEMBL27320681 | 0.74 | SHMT2 (0.53) | ALDH1A1HTTSHMT2MAP4K4HRH3 | |
| SCHEMBL27320181 | 0.73 | HRH3 (0.49) | ALDH1A1HTTHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |