Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27149452 | 0.82 | MAPK8 (0.35) | MAPK8MAPK14PDE2AOPRK1OPRM1 | |
| SCHEMBL31413385 | 0.82 | MAPK8 (0.35) | MAPK8MAPK14PDE2AOPRK1OPRM1 | |
| SCHEMBL27320131 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HTTMAP4K4HRH3MCHR1 | |
| SCHEMBL27319546 | 0.79 | HRH3 (0.41) | ALDH1A1HTTMAPK8MAPK14PDE2A | |
| SCHEMBL27320705 | 0.76 | ALDH1A1 (0.39) | ALDH1A1HTTMAP4K4PDE2AHRH3 | |
| SCHEMBL27320107 | 0.73 | CHKA (0.38) | ALDH1A1HTTHRH3MCHR1 | |
| SCHEMBL27150146 | 0.72 | MAPK8 (0.35) | MAPK8MAPK14GSK3B | |
| SCHEMBL31413434 | 0.72 | MAPK8 (0.35) | MAPK8MAPK14GSK3B | |
| SCHEMBL27320681 | 0.71 | SHMT2 (0.53) | ALDH1A1HTTMAP4K4PIK3CAHRH3 | |
| SCHEMBL27320489 | 0.70 | HSP90AB1 (0.42) | ALDH1A1PIK3CAMTORPDE2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |