Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 9/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27320131 | 0.79 | ALDH1A1 (0.41) | SHMT2ALDH1A1HTTHRH3KMT2A | |
| SCHEMBL27321251 | 0.79 | HRH3 (0.48) | GAAALDH1A1HRH3KMT2ASMN1; SMN2 | |
| SCHEMBL30718774 | 0.77 | SHMT2 (0.56) | SHMT2GAAKMT2ASMN1; SMN2ATR | |
| SCHEMBL27140115 | 0.77 | SHMT2 (0.56) | SHMT2GAAKMT2ASMN1; SMN2ATR | |
| SCHEMBL27320705 | 0.74 | ALDH1A1 (0.39) | SHMT2ALDH1A1HTTHRH3SMN1; SMN2 | |
| SCHEMBL27143319 | 0.73 | SHMT2 (0.53) | SHMT2GAAHTTSMN1; SMN2ATR | |
| SCHEMBL27143890 | 0.73 | SHMT2 (0.56) | SHMT2GAASMN1; SMN2PIK3CAATR | |
| SCHEMBL30718760 | 0.73 | SHMT2 (0.53) | SHMT2GAAHTTSMN1; SMN2ATR | |
| SCHEMBL30718849 | 0.73 | SHMT2 (0.56) | SHMT2GAASMN1; SMN2PIK3CAATR | |
| SCHEMBL27320384 | 0.71 | ALDH1A1 (0.37) | ALDH1A1HTTHRH3MAP4K4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |