Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174469 | 0.76 | CTNNB1 (0.40) | SIRT2SIRT1SIRT3 | |
| SCHEMBL8174331 | 0.74 | SIRT3 (0.47) | SYKSIRT2SIRT1SIRT3IRAK4 | |
| SCHEMBL30298688 | 0.74 | CYP46A1 (0.46) | SYKSIRT2SIRT1SIRT3IRAK4 | |
| SCHEMBL3544059 | 0.72 | NPC1 (0.49) | IRAK4 | |
| SCHEMBL1160541 | 0.72 | JAK1 (0.60) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2732237 | 0.72 | DHODH (0.42) | SYKJAK2 | |
| SCHEMBL2732238 | 0.72 | SYK (0.45) | PDE4BSYK | |
| SCHEMBL21816171 | 0.68 | MGLL (0.43) | — | |
| SCHEMBL2732234 | 0.68 | KDM4E (0.44) | PDE4BSYK | |
| SCHEMBL7090853 | 0.67 | LMNA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |