Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30298688 | 0.88 | CYP46A1 (0.46) | SIRT3TDP1CYP46A1IRAK4KDM4E | |
| SCHEMBL7090853 | 0.86 | LMNA (0.48) | TDP1CYP46A1KDM4ELMNAALDH1A1 | |
| SCHEMBL3544059 | 0.82 | NPC1 (0.49) | IRAK4KDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL21816147 | 0.81 | ALDH1A1 (0.48) | CYP46A1KDM4ELMNAALDH1A1MEN1 | |
| SCHEMBL885410 | 0.79 | SIRT3 (0.49) | SIRT3TDP1IRAK4KDM4ELMNA | |
| SCHEMBL7848026 | 0.78 | HCRTR1 (0.48) | SIRT3TDP1IRAK4KDM4ESYK | |
| SCHEMBL16666154 | 0.76 | NOTUM (0.46) | KDM4ELMNAALDH1A1MEN1GAA | |
| SCHEMBL15771021 | 0.75 | TDO2 (0.50) | TDP1CYP46A1KDM4ELMNAALDH1A1 | |
| SCHEMBL2732235 | 0.74 | CSF1R (0.44) | SIRT3IRAK4SYKSIRT2SIRT1 | |
| SCHEMBL8174469 | 0.74 | CTNNB1 (0.40) | SIRT3CYP46A1KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925322-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2015-10-07 | — | — | EP | claimed |
| CN-102933548-B | Carboxamide compounds and their use as calpain inhibitors | ABBOTT LAB | 2015-03-11 | — | — | CN | claimed |
| WO-2014085210-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2014-06-05 | — | — | WO | claimed |
| WO-2000031066-A1 | SUBSTITUTED N-PYRAZOLYL-PHENOXYNICOTINIC ACID-(THIO)AMIDES THAT CAN BE USED AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-02 | — | — | WO | claimed |
| CN-102933548-B | Carboxamide compounds and their use as calpain inhibitors | ABBOTT LAB | 2015-03-11 | — | — | CN | disclosed |
| WO-2000031066-A1 | SUBSTITUTED N-PYRAZOLYL-PHENOXYNICOTINIC ACID-(THIO)AMIDES THAT CAN BE USED AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-02 | — | — | WO | disclosed |