Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732234 | 0.79 | KDM4E (0.44) | SYKALDH1A1AURKAMAPK8LMNA | |
| SCHEMBL21438811 | 0.76 | ALDH1A1 (0.40) | MAPTALDH1A1MEN1GAAKMT2A | |
| SCHEMBL2732238 | 0.72 | SYK (0.45) | SYKMAPTNPC1AHRRAB9A | |
| SCHEMBL2732235 | 0.72 | CSF1R (0.44) | SYKJAK2 | |
| SCHEMBL21465577 | 0.69 | HCRTR1 (0.37) | MAPTALDH1A1MEN1GAAKMT2A | |
| SCHEMBL21439541 | 0.69 | LMNA (0.46) | MAPTALDH1A1MEN1GAAKMT2A | |
| SCHEMBL3544059 | 0.68 | NPC1 (0.49) | MAPTALDH1A1MEN1GAAKMT2A | |
| SCHEMBL15272776 | 0.68 | GAA (0.57) | SYKMAPTALDH1A1GAAKDM4E | |
| SCHEMBL17443085 | 0.68 | LMNA (0.40) | MAPTALDH1A1MEN1GAAKMT2A | |
| SCHEMBL479805 | 0.66 | DHODH (0.76) | DHODHMAPTALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |