SCHEMBL27325599

SCHEMBL27325599

CCC(=O)c1ccccc1C(Cl)(Cl)Cl

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.40
MAPT P10636 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HSP90AB1 P08238 1/20 0.39
TSHR P16473 1/20 0.38
CTNNB1 P35222 3/20 0.38
WNT3A P56704 3/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
KMT2A Q03164 1/20 0.37
ERCC5 P28715 1/20 0.37
FEN1 P39748 1/20 0.37
TP53 P04637 2/20 0.37
HPGD P15428 1/20 0.37
ALDH1A1 P00352 2/20 0.36
ABCB1 P08183 1/20 0.36
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11297486 0.82 ALDH1A1 (0.43) PDK2L3MBTL1MAPTSMN1; SMN2HSP90AB1
SCHEMBL29410857 0.81 CTNNB1 (0.57) PDK2CTNNB1WNT3A
SCHEMBL1950901 0.81 CTNNB1 (0.57) PDK2CTNNB1WNT3A
SCHEMBL28523326 0.81 PDK2 (0.41) PDK2L3MBTL1MAPTSMN1; SMN2HSP90AB1
Hydrochloric Acid SCHEMBL5819908 0.79 CTNNB1 (0.55) PDK2CTNNB1WNT3A
SCHEMBL13990159 0.79 L3MBTL1 (0.52) PDK2L3MBTL1MAPTSMN1; SMN2HSP90AB1
SCHEMBL2837238 0.78 ERCC5 (0.58) MAPTSMN1; SMN2CES2CES1KMT2A
SCHEMBL3904036 0.77 CES2 (0.44) L3MBTL1MAPTSMN1; SMN2TSHRCES2
SCHEMBL7280670 0.77 TSHR (0.54) L3MBTL1MAPTHSP90AB1TSHRKMT2A
Water SCHEMBL7994046 0.76 ERCC5 (0.56) MAPTSMN1; SMN2CES2CES1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1049884-C Synthesis process of methylbenzyl acetone trihalide PUDONG PHARMACEUTICAL FACTORY (CN) 2000-03-01 CN disclosed
CN-1174187-A Synthesis process of methylbenzyl acetone trihalide PUDONG PHARMACEUTICAL FACTORY (CN) 1998-02-25 CN disclosed