SCHEMBL2732801

SCHEMBL2732801

CCC(N(C(=O)NNS(=O)(=O)c1cccc2ccccc12)C(CC)C(F)(F)F)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 11/20 0.48
KCNA5 P22460 1/20 0.42
RORA P35398 1/20 0.41
RORC P51449 1/20 0.41
NR1H2 P55055 1/20 0.41
NR1H4 Q96RI1 1/20 0.41
HCRTR1 O43613 1/20 0.41
SLC1A3 P43003 1/20 0.40
SLC1A2 P43004 1/20 0.40
SLC1A1 P43005 1/20 0.40
GBA1 P04062 1/20 0.40
PREP P48147 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
SCN1A P35498 1/20 0.39
SCN2A Q99250 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2732491 0.86 HDAC4 (0.47) GBA1CYP1A2CYP2C19
SCHEMBL2732838 0.77 MMP1 (0.46)
SCHEMBL2732799 0.75 RORA (0.41) SLC6A9RORARORCNR1H2NR1H4
SCHEMBL2733097 0.74 KAT6A (0.51) ALDH1A1
SCHEMBL2732636 0.74 KAT6A (0.37) SLC1A3SLC1A2SLC1A1KDM4EALDH1A1
SCHEMBL420581 0.74 MAPT (0.49) SLC6A9KCNA5RORARORCNR1H2
SCHEMBL2732878 0.73 NR3C1 (0.44) CYP3A4
SCHEMBL8561210 0.69 HCRTR1 (0.51) SLC6A9KCNA5HCRTR1SLC1A3SLC1A2
SCHEMBL2878189 0.68 SCN1A (0.59) SLC6A9HCRTR1GBA1KDM4EALDH1A1
SCHEMBL15127594 0.67 SLC6A9 (0.57) SLC6A9SLC1A3SLC1A2SLC1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012060820-A1 SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES SIGA TECHNOLOGIES, INC. (US) 2012-05-10 WO claimed
WO-2012060820-A1 SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES SIGA TECHNOLOGIES, INC. (US) 2012-05-10 WO disclosed