Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | ACR | P10323 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729152 | 0.89 | PRSS1 (0.55) | PRSS1ACRSMN1; SMN2ADAMTS4HPGD | |
| Carbamic Acid Phenyl Ester SCHEMBL27925745 | 0.80 | MEN1 (0.55) | PRSS1ACRSMN1; SMN2ADAMTS4HPGD | |
| SCHEMBL5699582 | 0.76 | SMN1; SMN2 (0.54) | PRSS1ACRSMN1; SMN2HPGDXBP1 | |
| SCHEMBL2733407 | 0.76 | SMN1; SMN2 (0.49) | PRSS1ACRSMN1; SMN2HPGDXBP1 | |
| SCHEMBL5933312 | 0.74 | SMN1; SMN2 (0.53) | PRSS1ACRSMN1; SMN2HPGDXBP1 | |
| Hydrochloric Acid SCHEMBL11848676 | 0.74 | SMN1; SMN2 (0.53) | PRSS1ACRSMN1; SMN2HPGDXBP1 | |
| Hydrogen Peroxide SCHEMBL9578945 | 0.74 | LMNA (0.57) | PRSS1ACRSMN1; SMN2HPGDXBP1 | |
| SCHEMBL236821 | 0.74 | SMN1; SMN2 (0.56) | PRSS1ACRSMN1; SMN2HPGDXBP1 | |
| SCHEMBL10879322 | 0.74 | SRD5A2 (0.53) | SMN1; SMN2LMNAMEN1KMT2AELANE | |
| SCHEMBL6284986 | 0.73 | KMT2A (0.64) | PRSS1SMN1; SMN2ADAMTS4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096316-A1 | Novel Method for Preparation of Bisnorcymerine and Salts Thereof | QR PHARMA, INC. | 2013-04-18 | — | — | US | disclosed |
| WO-2012058031-A2 | NOVEL METHOD FOR PREPARATION OF BISNORCYMERINE AND SALTS THEREOF | QR PHARMA, INC. (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096316-A1 | Novel Method for Preparation of Bisnorcymerine and Salts Thereof | PHOSPHO1, CBS, COASY | PRSS1 225/4885ACR 1980/4885SMN1; SMN2 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.