Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 5/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | MATK | P42679 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27336325 | 0.99 | TOP2A (0.47) | TOP2ATOP2BGSK3BKCNH2CACNA1F | |
| Hydrochloric Acid SCHEMBL27422188 | 0.87 | TOP2A (0.43) | TOP2ATOP2BGSK3BKCNH2CACNA1F | |
| SCHEMBL27344759 | 0.82 | PIM3 (0.35) | TOP2ATOP2BMEN1KMT2ARPS6KB1 | |
| SCHEMBL27345669 | 0.82 | LMNA (0.46) | TOP2ATOP2BMAPK1MEN1KMT2A | |
| SCHEMBL27323317 | 0.81 | GSK3B (0.52) | TOP2ATOP2BGSK3BKCNH2CACNA1F | |
| SCHEMBL27323899 | 0.81 | LMNA (0.37) | TOP2ATOP2BGSK3BPOLBMEN1 | |
| SCHEMBL5874340 | 0.79 | TOP2A (0.53) | TOP2ATOP2BGSK3BKCNH2CACNA1F | |
| SCHEMBL9088107 | 0.79 | PIM3 (0.65) | TOP2ATOP2BGSK3BKCNH2CACNA1F | |
| SCHEMBL27335100 | 0.79 | PIM3 (0.65) | TOP2ATOP2BGSK3BKCNH2CACNA1F | |
| SCHEMBL9090016 | 0.78 | KCNH2 (0.54) | TOP2ATOP2BGSK3BKCNH2CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1045972-A | 5-replaces-1,4-dihydro-4-oxo-naphthyridine-3-carboxylic acid (ester) antimicrobial drug | BRISTOL MYERS SQUIBB CO (US) | 1990-10-10 | — | — | CN | disclosed |