Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.38 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2132159 | 1.00 | HSD11B1 (0.42) | HSD11B1NPC1RAB9AATMPIK3CD | |
| SCHEMBL2131592 | 0.95 | PIK3CD (0.42) | PIK3CDDGAT1PTPN1PTPN2PIK3CA | |
| SCHEMBL2133298 | 0.93 | PIK3CD (0.41) | HSD11B1RAB9APIK3CDDGAT1PIK3CA | |
| SCHEMBL2133254 | 0.91 | MCHR1 (0.42) | PIK3CDSMODRD2DRD4ADAMTS4 | |
| SCHEMBL2136227 | 0.88 | ADAMTS7 (0.43) | SMOADAMTS7ADAMTS5 | |
| SCHEMBL2129161 | 0.88 | PIK3CD (0.41) | HSD11B1NPC1RAB9AATMPIK3CD | |
| SCHEMBL2137397 | 0.88 | LMNA (0.44) | HSD11B1NPC1RAB9AATMPIK3CD | |
| SCHEMBL2133554 | 0.86 | PRSS12 (0.42) | PRSS12EPHX1 | |
| SCHEMBL2133028 | 0.85 | EPHX1 (0.44) | NPC1RAB9APIK3CDPRSS12PIK3CA | |
| SCHEMBL2143188 | 0.85 | EPHX1 (0.44) | NPC1RAB9APIK3CDPRSS12PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630139-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-08-28 | — | — | EP | disclosed |
| WO-2012054721-A1 | AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICAL NV (BE) | 2012-04-26 | — | — | WO | disclosed |