Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 4/20 | 0.42 |
| ▸ | HTR1B | P28222 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618496 | 0.82 | CYP1A2 (0.63) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL12127418 | 0.81 | KDM4E (0.49) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL892836 | 0.81 | OPRM1 (0.53) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL4674153 | 0.81 | HSD11B1 (0.60) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL6212815 | 0.81 | HTR1D (0.62) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL30567991 | 0.81 | OPRM1 (0.53) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL28380406 | 0.80 | MTNR1A (0.61) | ALDH1A1MAPTHTR1ALMNAHSD11B1 | |
| Hydrochloric Acid SCHEMBL1703941 | 0.80 | OPRM1 (0.52) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2263846 | 0.79 | CCR2 (0.52) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL21384720 | 0.79 | KDM4E (0.47) | KDM4EBRD4ALDH1A1POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1051313-C | 5-arylindole derivatives | PFIZER (US) | 2000-04-12 | — | — | CN | disclosed |
| CN-1094727-A | The 5-(hetero) aryl indole derivatives | PFIZER (US) | 1994-11-09 | — | — | CN | disclosed |