Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27353154 | 0.83 | POLB (0.53) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL1155787 | 0.80 | MDM2 (0.55) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL27320127 | 0.79 | MAPK9 (0.50) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL17086633 | 0.79 | MDM2 (0.52) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL7067937 | 0.77 | KDR (0.48) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL12759885 | 0.76 | MDM2 (0.52) | MDM2NR3C2MAPK9MAPK10MAPK8 | |
| SCHEMBL27323106 | 0.75 | PDE10A (0.48) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL27315071 | 0.75 | MAPK9 (0.68) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL27519346 | 0.75 | NR3C2 (0.47) | MDM2NR3C2POLBMAPK9MAPK10 | |
| SCHEMBL27730925 | 0.75 | ALDH1A1 (0.55) | MDM2NR3C2POLBMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1031570-C | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-04-17 | — | — | CN | disclosed |
| CN-1044656-A | Pyrazolopyridine compound and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-08-15 | — | — | CN | disclosed |