Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 6/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 6/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27354578 | 0.85 | PPARA (0.36) | PPARARARARARBKDM4EPTPN11 | |
| SCHEMBL31476929 | 0.81 | ALDH1A1 (0.39) | RARARARBKDM4EPTPN11PTPN1 | |
| SCHEMBL27354582 | 0.80 | CRBN (0.43) | RARARARB | |
| SCHEMBL31476875 | 0.76 | WDR5 (0.38) | RARARARBKDM4EPTPN11PTPN1 | |
| SCHEMBL30696727 | 0.72 | KDM4E (0.41) | RARARARBKDM4EPTPN11ALDH1A1 | |
| SCHEMBL27356789 | 0.68 | BCHE (0.41) | KDM4E | |
| SCHEMBL30696747 | 0.67 | MAPT (0.43) | KDM4EALDH1A1 | |
| SCHEMBL27355404 | 0.65 | CXCL12 (0.38) | KDM4EALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL31490890 | 0.64 | SRD5A2 (0.57) | RARARARBKDM4EALDH1A1KMT2A | |
| SCHEMBL25142884 | 0.64 | TTR (0.41) | RARARARBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543439-A2 | NRF2 PROTEIN DEGRADERS | Ganymede Oncology, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119730847-A | NRF2 protein degradation agent | 盖尼米德肿瘤学股份有限公司 | 2025-03-28 | — | — | CN | disclosed |
| WO-2024006742-A2 | NRF2 PROTEIN DEGRADERS | DRACEN PHARMACEUTICALS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |
| WO-2024006742-A2 | NRF2 PROTEIN DEGRADERS | DRACEN PHARMACEUTICALS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |