Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947022 | 0.82 | F10 (0.55) | TNFCTNNB1KDM4ECNR1GAA | |
| SCHEMBL27343262 | 0.80 | KDM4E (0.54) | KDM4EL3MBTL1TBXAS1 | |
| SCHEMBL27431550 | 0.79 | PSEN1 (0.38) | KDM4EPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12938925 | 0.73 | TNF (0.64) | TNFCTNNB1KDM4ECNR1PSEN1 | |
| SCHEMBL7961092 | 0.73 | F10 (0.55) | CTNNB1KDM4EGAAMEN1KMT2A | |
| SCHEMBL1004093 | 0.72 | TNF (0.63) | TNFCTNNB1KDM4ECNR1PSEN1 | |
| SCHEMBL1004476 | 0.72 | TNF (0.63) | TNFCTNNB1KDM4ECNR1PSEN1 | |
| SCHEMBL8693113 | 0.70 | TNF (0.60) | TNFCTNNB1KDM4ECNR1GAA | |
| SCHEMBL8693185 | 0.70 | MCL1 (0.58) | TNFCTNNB1KDM4ECNR1GAA | |
| SCHEMBL355499 | 0.69 | TNF (0.62) | TNFCTNNB1KDM4ECNR1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1058969-C | Novel substd. guanidine derivs., process for prodn. thereof, and pharmaceutical uses thereof | SUMITOMO PHARMA (JP) | 2000-11-29 | — | — | CN | disclosed |