Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.49 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693304 | 0.84 | KDM4E (0.60) | CTNNB1KDM4EALDH1A1TSHR | |
| SCHEMBL12938925 | 0.81 | TNF (0.64) | TNFCTNNB1KDM4EFABP4FABP5 | |
| SCHEMBL1004476 | 0.80 | TNF (0.63) | TNFCTNNB1KDM4EFABP4FABP5 | |
| SCHEMBL1004093 | 0.80 | TNF (0.63) | TNFCTNNB1KDM4EFABP4FABP5 | |
| SCHEMBL3679623 | 0.78 | ALDH1A1 (0.54) | KDM4EFABP4FABP5ALDH1A1TSHR | |
| SCHEMBL21647533 | 0.78 | PTGER4 (0.51) | KDM4EGAAALDH1A1TSHR | |
| SCHEMBL21647636 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1TSHR | |
| SCHEMBL355499 | 0.77 | TNF (0.62) | TNFCTNNB1KDM4EFABP4FABP5 | |
| SCHEMBL1128275 | 0.77 | FNTA (0.68) | TNFCTNNB1KDM4EFABP4FABP5 | |
| SCHEMBL7308089 | 0.77 | TNF (0.62) | TNFCTNNB1KDM4ECNR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760032-A | GASTROINTESTINAL DISORDERS AND NERVOUS SYSTEM DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| EP-0776892-A1 | THIENYLAZOLE COMPOUND AND THIENOTRIAZOLODIAZEPINE COMPOUND | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-06-04 | — | — | EP | disclosed |