SCHEMBL27360402

SCHEMBL27360402

C#Cc1ccc(S(C)(=O)=O)c([Si](C)(C)C)c1

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.36
CA12 O43570 2/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
CA14 Q9ULX7 2/20 0.35
CA4 P22748 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
HDAC8 Q9BY41 1/20 0.30
TYMS P04818 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9538194 0.72 KEAP1 (0.35) CYP2C9HDAC8TYMS
SCHEMBL9394396 0.71 HDAC8 (0.32) CYP2C9CA12CA1CA2CA9
SCHEMBL15491231 0.70 CA12 (0.36) CYP2C9CA12CA1CA2CA9
SCHEMBL29752544 0.69 KEAP1 (0.33) HDAC8
SCHEMBL11235361 0.66 CYP2C9 (0.36) CYP2C9CA12CA1CA2CA9
SCHEMBL28641198 0.66 GABRA1 (0.40)
SCHEMBL253713 0.65 CA12 (0.61) CYP2C9CA12CA1CA2CA9
SCHEMBL11231894 0.65 PTGS2 (0.38) CA12CA1CA2CA9CA14
SCHEMBL5700009 0.64 HDAC8 (0.39) CYP2C9CA12CA1CA2CA9
SCHEMBL11230356 0.64 PTGS2 (0.40) CA12CA1CA2CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1227244-C Herbicidal benzoyl derivatives BASF AG (DE) 2005-11-16 CN disclosed
CN-1071757-C Pyrazolylbenzoyl derivatives BASF AG (DE) 2001-09-26 CN disclosed
CN-1179778-A Herbicidal benzoyl derivatives BASF AG (DE) 1998-04-22 CN disclosed
CN-1175951-A Pyrazol-4 -yl -benzoyl derivatives BASF AG (DE) 1998-03-11 CN disclosed