Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terbutaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.79 |
| ▸ | LMNA | P02545 | 5/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.79 |
| ▸ | TSHR | P16473 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | CASP7 | P55210 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | BLM | P54132 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | CASP1 | P29466 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terbutaline SCHEMBL28876660 | 0.91 | LMNA (0.79) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL16553265 | 0.89 | LMNA (0.81) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL41869 | 0.89 | LMNA (1.00) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL13327959 | 0.89 | LMNA (1.00) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL4391 | 0.89 | LMNA (1.00) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL404480 | 0.87 | ADRB2 (0.96) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL11703058 | 0.87 | ADRB2 (0.96) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL5530880 | 0.85 | LMNA (0.89) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL4902064 | 0.85 | LMNA (0.94) | ADRB2LMNAHIF1ATSHRKMT2A | |
| Terbutaline SCHEMBL9666580 | 0.85 | LMNA (0.94) | ADRB2LMNAHIF1ATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102512676-A | Methods of using a thiazole derivative | OTSUKA PHARMA CO LTD | 2012-06-27 | — | — | CN | claimed |
| CN-101472570-A | Methods of using thiazole derivatives | OTSUKA PHARMA CO LTD (JP) | 2009-07-01 | — | — | CN | claimed |
| CN-1839833-A | Pharmaceutical compositions based on anticholinergically effective compounds and beta-mimetics | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-10-04 | — | — | CN | claimed |
| CN-1688308-A | Inhalation medicaments containing a novel anticholinesterase drug in conjunction with corticosteroids and betamimetic drugs | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-10-26 | — | — | CN | claimed |
| CN-1120841-C | Medicine composition and use thereof | BOEHRINGER INGELHEIM KG (DE) | 2003-09-10 | — | — | CN | claimed |
| CN-1350465-A | Novel pharmaceutical compositions based on anticholinergically effective compounds and beta-mimetics | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-05-22 | — | — | CN | claimed |
| CN-1191535-A | Novel pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM KG (DE) | 1998-08-26 | — | — | CN | claimed |
| CN-102892765-B | Cyclohexylamine derivatives having beta 2 adrenergic agonist and M3 muscarinic antagonist activity | ALMIRALL SA | 2015-04-29 | — | — | CN | disclosed |
| CN-102892765-A | Novel cyclohexylamine derivatives having beta 2 adrenergic agonist and M3 muscarinic antagonist activity | ALMIRALL SA | 2013-01-23 | — | — | CN | disclosed |
| CN-102512676-A | Methods of using a thiazole derivative | OTSUKA PHARMA CO LTD | 2012-06-27 | — | — | CN | disclosed |
| CN-101472570-A | Methods of using thiazole derivatives | OTSUKA PHARMA CO LTD (JP) | 2009-07-01 | — | — | CN | disclosed |
| CN-101296701-A | A combination of compounds, which can be used in the treatment of respiratory diseases, especially chronic obstructive pulmonary disease (COPD) and asthma | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | CN | disclosed |
| CN-101296698-A | Combination of compounds for the treatment of respiratory diseases, in particular Chronic Obstructive Pulmonary Disease (COPD) and asthma | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | CN | disclosed |
| CN-1085525-C | Air pressed package using polyoxyethylene glyceryl oleate | ASTM PHARMACEUTICAL CO LTD (DE) | 2002-05-29 | — | — | CN | disclosed |
| CN-1350465-A | Novel pharmaceutical compositions based on anticholinergically effective compounds and beta-mimetics | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-05-22 | — | — | CN | disclosed |
| CN-1069191-C | Compressed air packaging using polyoxyethylene glyceryl oleate | ASTA MEDICA AG (DE) | 2001-08-08 | — | — | CN | disclosed |
| CN-1306420-A | Methods for treating capules and dry powdered pharmaceutical formulations | BOEHRINGER INGELHEIM PHARMA (US) | 2001-08-01 | — | — | CN | disclosed |
| CN-1259342-A | Air pressed package using polyoxyethylene glyceryl oleate | ASTA PHARMACEUTICAL CO LTD (DE) | 2000-07-12 | — | — | CN | disclosed |
| CN-1259343-A | Air pressed package using polyoxyethylene glyceryl oleate | ASTA PHARMACEUTICAL CO LTD (DE) | 2000-07-12 | — | — | CN | disclosed |
| CN-1080846-A | Compressed air packaging using polyoxyethylene glyceryl oleate | ASTA MEDICA AG (DE) | 1994-01-19 | — | — | CN | disclosed |