SCHEMBL27362947

SCHEMBL27362947

Cc1cccc(C)c1-c1nnn[nH]1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.34
GAA P10253 1/20 0.32
CD44 P16070 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2A6 P11509 1/20 0.32
SRC P12931 2/20 0.32
ALDH1A1 P00352 2/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
TSHR P16473 1/20 0.31
ACHE P22303 1/20 0.31
BRD4 O60885 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
NOS3 P29474 1/20 0.30
NOS1 P29475 1/20 0.30
NOS2 P35228 1/20 0.30
FGFR1 P11362 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19147993 0.85 SRC (0.38) GAASRCGRIA1CACNG8
SCHEMBL18234388 0.82 L3MBTL1 (0.33)
SCHEMBL16947363 0.82
SCHEMBL24573404 0.81 ALDH1A1 (0.30) ALDH1A1SMN1; SMN2
SCHEMBL29483300 0.79 P2RX7 (0.39) NPSR1GAAALDH1A1TDP1SMN1; SMN2
SCHEMBL5813250 0.79 P2RX7 (0.39) NPSR1GAAALDH1A1TDP1SMN1; SMN2
SCHEMBL9131572 0.78 LMNA (0.43) NPSR1CD44CYP1A2ALDH1A1TDP1
SCHEMBL918324 0.78 DCUN1D1 (0.47) NPSR1GAAALDH1A1TSHRSMN1; SMN2
SCHEMBL19596698 0.76 NPC1 (0.33) TDP1SMN1; SMN2
SCHEMBL5815118 0.75 JAK2 (0.41) GAACYP1A2CYP2A6NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024026483-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed