Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | QDPR | P09417 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759154 | 0.90 | CCR2 (0.51) | CCR2CCR5DRD2TLR9TLR8 | |
| SCHEMBL27364866 | 0.88 | DRD2 (0.46) | CCR2CCR5DRD2SLC18A3DRD4 | |
| SCHEMBL22542118 | 0.87 | SLC18A3 (0.53) | CCR2CCR5DRD2TLR9TLR8 | |
| SCHEMBL25583834 | 0.86 | DRD2 (0.45) | CCR5DRD2TLR9TLR8TLR7 | |
| SCHEMBL27365222 | 0.86 | CCR2 (0.41) | CCR2CCR5DRD2TLR9TLR8 | |
| SCHEMBL81500 | 0.85 | QDPR (0.56) | DRD2LSSQDPRSLC18A3 | |
| SCHEMBL17432874 | 0.84 | CCR2 (0.47) | CCR2CCR5DRD2TLR9TLR8 | |
| SCHEMBL27364224 | 0.84 | DRD2 (0.48) | DRD2LSSDRD4DRD3 | |
| SCHEMBL25632063 | 0.83 | CCR2 (0.49) | CCR2CCR5DRD2TLR9TLR8 | |
| SCHEMBL27365089 | 0.82 | DRD2 (0.51) | CCR5DRD2TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |