Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363818 | 0.85 | MAPK1 (0.47) | MAPK1MAPTDRD2DRD4CACNA2D1 | |
| SCHEMBL12697214 | 0.71 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTKCNH2CHRM4 | |
| SCHEMBL12697210 | 0.71 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTKCNH2CHRM4 | |
| SCHEMBL27363269 | 0.71 | CASP1 (0.41) | KCNH2CHRM4DRD3DRD2CACNA2D1 | |
| SCHEMBL27367505 | 0.71 | MAPK1 (0.43) | MAPK1MAPTDRD2DRD4CACNA2D1 | |
| SCHEMBL26251330 | 0.70 | HRH3 (0.49) | CHRNB2CHRNA4KCNH2CHRNB4CHRNA3 | |
| SCHEMBL12697193 | 0.70 | CHRNB2 (0.44) | CHRNB2CHRNA4MAPTCHRM4CHRNB1 | |
| SCHEMBL27365978 | 0.70 | MAPK1 (0.42) | MAPK1MAPTCHRM4DRD2DRD4 | |
| SCHEMBL25141735 | 0.69 | NCF1 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL26517429 | 0.69 | NCF1 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |