Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300492 | 0.78 | KDM4E (0.51) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL18404931 | 0.75 | HSD17B10 (0.59) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL28684373 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL16943501 | 0.72 | ALDH1A1 (0.71) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL27939080 | 0.71 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL27459777 | 0.71 | ADRA2A (0.53) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL26646738 | 0.71 | MAPT (0.53) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL26227993 | 0.70 | HSD17B10 (0.56) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL3107611 | 0.70 | PRNP (0.71) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL19193144 | 0.70 | HTR7 (0.53) | HSD17B10KMT2AMEN1GAASIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067986-C | 1H-indole-3-acetic acid hydrazide spla2 inhibitors | LILLY CO ELI (US) | 2001-07-04 | — | — | CN | disclosed |
| CN-1098714-A | The 1H-indole-3-acetic acid hydrazide spla 2 inhibitors | LILLY CO ELI (US) | 1995-02-15 | — | — | CN | disclosed |