Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | PPARG | P37231 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.71 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.71 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.71 |
| ▸ | EGFR | P00533 | 4/20 | 0.62 |
| ▸ | CDK2 | P24941 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449433 | 0.86 | KDM4E (0.73) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL30890023 | 0.86 | KDM4E (0.73) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL1553071 | 0.84 | NPSR1 (0.71) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL16943501 | 0.84 | ALDH1A1 (0.71) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL20094576 | 0.84 | KDM4E (0.70) | EGFRKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL14865011 | 0.83 | MAPT (0.60) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL2538695 | 0.83 | PRNP (0.69) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL8959541 | 0.83 | PRNP (0.69) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL1894184 | 0.83 | RXFP1 (1.00) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL3091494 | 0.82 | KDM4E (0.66) | PRNPCYP1A2CYP2C9CYP2C19PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220412952-A1 | USE OF A CHEMIRESISTOR SENSOR FOR IMPROVING HEALTH | NANOSCENT LTD. (IL) | 2022-12-29 | — | — | US | disclosed |
| WO-2021111435-A9 | USE OF A CHEMIRESISTOR SENSOR FOR IMPROVING HEALTH | NANOSCENT LTD. (IL) | 2021-09-10 | — | — | WO | disclosed |
| WO-2021111435-A1 | USE OF A CHEMIRESISTOR SENSOR FOR IMPROVING HEALTH | NANOSCENT LTD. (IL) | 2021-06-10 | — | — | WO | disclosed |
| US-8071622-B2 | 1-[1-(6-Methoxy-1H-indole-2-carbonyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one; vasopressin receptors antagonist; antidepressant, anxiolytic agent; dysmenorrhea, hypertension, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder | HOFFMAN-LA ROCHE INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-7799923-B2 | Vasopressin receptor antagonists; (4-Benzotriazol-1-yl-piperidin-1-yl)-(5-chloro-1H-indol-2-yl)-methanone; antidepressants, anxiolytic agents; dysmenorrhea, hypertension, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder | HOFFMANN-LA ROCHE INC. (US) | 2010-09-21 | — | — | US | disclosed |
| EP-2089381-B1 | INDOLES WHICH ACT AS VIA RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| CN-101541786-A | Indoles as V1a receptor antagonists | HOFFMANN LA ROCHE (CH) | 2009-09-23 | — | — | CN | disclosed |
| EP-2089381-A1 | INDOLES WHICH ACT AS VIA RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| US-20080269290-A1 | Indoles | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-30 | — | — | US | disclosed |
| US-20080139618-A1 | INDOLES | HOFFMAN-LA ROCHE INC. | 2008-06-12 | — | — | US | disclosed |
| WO-2008068184-A1 | INDOLES WHICH ACT AS VIA RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |
| US-20080139548-A1 | INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | US | disclosed |
| US-20080139617-A1 | INDOLES | HOFFMAN-LA ROCHE INC. | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139548-A1 | INDOLES | HTR1A, AVPR1A, TPH1 | PRNP 1687/4885CYP1A2 210/4885CYP2C9 768/4885 |
| US-20080139617-A1 | INDOLES | HTR1A, AVPR1A, TPH1 | PRNP 1687/4885CYP1A2 210/4885CYP2C9 768/4885 |
| US-20080269290-A1 | Indoles | HTR1A, AVPR1A, TPH1 | PRNP 1687/4885CYP1A2 210/4885CYP2C9 768/4885 |
| US-20080139618-A1 | INDOLES | HTR1A, AVPR1A, TPH1 | PRNP 1687/4885CYP1A2 210/4885CYP2C9 768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.