SCHEMBL27366858

SCHEMBL27366858

COc1cnc2cccc(CCN)c2c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1B P49286 9/20 0.65
MTNR1A P48039 8/20 0.65
TAAR1 Q96RJ0 3/20 0.44
HTR2A P28223 2/20 0.43
CYP1A2 P05177 1/20 0.43
HTR1A P08908 1/20 0.43
MAPT P10636 1/20 0.43
TSHR P16473 1/20 0.43
NFKB1 P19838 1/20 0.43
HTR1D P28221 1/20 0.43
HTR1B P28222 1/20 0.43
HTR2C P28335 1/20 0.43
HTR7 P34969 1/20 0.43
HTR6 P50406 1/20 0.43
HTR4 Q13639 1/20 0.43
TRPM8 Q7Z2W7 1/20 0.43
ADRA1A P35348 1/20 0.43
BLM P54132 1/20 0.43
PMP22 Q01453 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14400285 0.83 MTNR1B (0.64) MTNR1BMTNR1AMAPTNPSR1
SCHEMBL27366855 0.83 HTR2A (0.60) MTNR1BMTNR1AHTR2ACYP1A2HTR1A
SCHEMBL591672 0.82 MTNR1A (0.62) MTNR1BMTNR1AHTR2AHTR2C
SCHEMBL591634 0.81 MTNR1A (0.68) MTNR1BMTNR1A
SCHEMBL591578 0.78 MTNR1A (0.62) MTNR1BMTNR1ATAAR1HTR2ACYP1A2
SCHEMBL31325737 0.77 TAAR1 (0.43) MTNR1BMTNR1ATAAR1HTR2AHTR1A
SCHEMBL5265681 0.76 MTNR1B (0.51) MTNR1BMTNR1AMAPTBLMNPSR1
SCHEMBL31331827 0.76 MTNR1B (0.56) MTNR1BMTNR1AMAPTNPSR1
SCHEMBL27366827 0.76 MTNR1B (0.56) MTNR1BMTNR1AMAPTNPSR1
SCHEMBL22766493 0.74 MTNR1B (0.50) MTNR1BMTNR1ACYP1A2MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250333371-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-10-30 US disclosed
EP-4532462-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-04-09 EP disclosed
CN-119384406-A Compounds of formula (I) 赛洛私人有限公司 2025-01-28 CN disclosed
WO-2023230649-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-12-07 WO disclosed
WO-2023230649-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-12-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250333371-A1 COMPOUNDS SDHA, PYGB, SLC18A2 MTNR1B 757/4885MTNR1A 1247/4885TAAR1 647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.