Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27534236 | 0.88 | POLB (0.41) | MEN1KMT2ARAB9ATACR1PRKCB | |
| SCHEMBL27392325 | 0.87 | TACR1 (0.40) | LMNAMAPTTACR1PRKCBGSK3B | |
| SCHEMBL27368420 | 0.87 | KDM4E (0.39) | RAB9ATACR1PRKCBGSK3BALDH1A1 | |
| SCHEMBL27393240 | 0.83 | JAK2 (0.40) | MEN1KMT2ADPP4 | |
| SCHEMBL27392323 | 0.80 | MAP2 (0.40) | MEN1KMT2ARAB9ALMNAMAPT | |
| SCHEMBL27398847 | 0.78 | KDM4E (0.38) | MAPTTACR1PRKCBGSK3BKDM4E | |
| SCHEMBL6634786 | 0.74 | PRKCB (0.44) | RAB9ATACR1PRKCBGSK3BALDH1A1 | |
| SCHEMBL27389832 | 0.73 | RXFP1 (0.42) | KMT2ALMNAMAPTDPP4 | |
| SCHEMBL27370786 | 0.72 | TP53 (0.43) | KMT2AMAPTDPP4TP53 | |
| SCHEMBL27366469 | 0.72 | ACAT1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1065243-C | Naphthyridine derivs. | SUMITOMO PHARMA (JP) | 2001-05-02 | — | — | CN | disclosed |
| CN-1191536-A | Naphthyridine derivs. | SUMITOMO PHARMA (JP) | 1998-08-26 | — | — | CN | disclosed |