Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736546 | 0.87 | LMNA (0.44) | LMNACYP1A2CYP3A4MAOAHPGD | |
| SCHEMBL12309517 | 0.86 | — | — | |
| SCHEMBL10208262 | 0.84 | HPGD (0.46) | HPGDHTTSRCMAPTALDH1A1 | |
| SCHEMBL2737112 | 0.81 | TDP1 (0.47) | PTGER4LMNAHPGDSMN1; SMN2TDP1 | |
| SCHEMBL2737105 | 0.79 | CA12 (0.51) | LMNACYP1A2CYP3A4MAOAHPGD | |
| SCHEMBL2736511 | 0.77 | HPGD (0.47) | LMNACYP1A2CYP3A4MAOAHPGD | |
| SCHEMBL2737111 | 0.76 | MAPT (0.49) | LMNAHPGDHTTSRCMAPT | |
| SCHEMBL10207671 | 0.76 | EGFR (0.48) | LMNAHTTSRCMAPTSMN1; SMN2 | |
| SCHEMBL2736681 | 0.74 | SMN1; SMN2 (0.46) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL2737175 | 0.74 | HSD17B2 (0.44) | LMNACYP1A2CYP3A4MAOAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402314-A1 | (Aza)indole derivative and use thereof for medical purposes | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |