Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PRNP | P04156 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazolinone SCHEMBL10418 | 0.86 | PARP1 (0.48) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL7746268 | 0.84 | PARP1 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL28241793 | 0.84 | PARP1 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL8201415 | 0.84 | PARP1 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL7744396 | 0.83 | PARP1 (0.46) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL27370560 | 0.77 | PBRM1 (0.46) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL27387957 | 0.77 | PBRM1 (0.42) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Quinazolinone SCHEMBL5266556 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL28111344 | 0.75 | KDM4E (0.41) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL18329383 | 0.75 | HPGD (0.40) | SMN1; SMN2PDPK1CA12PARP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066847-A | Angiotensin-ii receptor blockers 2,3,6 quinazolinones that replace | AMERICAN CYANAMID CO (US) | 1992-12-09 | — | — | CN | disclosed |